Orthopaedics and Trauma
Volume 24, Issue 2 , Pages 149-163 , April 2010

Current management of long bone large segmental defects

References 

  1. Reichert JC, et al. The challenge of establishing preclinical models for segmental bone defect research. Biomaterials. 2009;30:2149–2163
  2. Rimondini L, et al. In vivo experimental study on bone regeneration in critical bone defects using an injectable biodegradable PLA/PGA copolymer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:148–154
  3. Gugala Z, Gogolewski S. Regeneration of segmental diaphyseal defects in sheep tibiae using resorbable polymeric membranes: a preliminary study. J Orthop Trauma. 1999;13:187–195
  4. Gugala Z, Lindsey RW, Gogolewski S. New approaches in the treatment of critical-size segmental defects in long bones. In” Macromol Symp, 2007: 147–61.
  5. Lindsey RW, et al. The efficacy of cylindrical titanium mesh cage for the reconstruction of a critical-size canine segmental femoral diaphyseal defect. J Orthop Res. 2006;24:1438–1453
  6. Kakinoki R, et al. Reconstruction of a phalangeal bone using a vascularised metacarpal bone graft nourished by a dorsal metacarpal artery. Injury. 2008;39:25–28
  7. Lasanianos N, Mouzopoulos G, Garnavos C. The use of freeze-dried cancelous allograft in the management of impacted tibial plateau fractures. Injury. 2008;39:1106–1112
  8. Martinez AA, et al. Allograft reconstruction of segmental defects of the humeral head associated with posterior dislocations of the shoulder. Injury. 2008;39:319–322
  9. Oh JK, et al. Treatment of femoral and tibial diaphyseal nonunions using reamed intramedullary nailing without bone graft. Injury. 2008;39:952–959
  10. Talbot M, et al. Fixation of long bone segmental defects: a biomechanical study. Injury. 2008;39:181–186
  11. Keating JF, Simpson AH, Robinson CM. The management of fractures with bone loss. J Bone Joint Surg Br. 2005;87:142–150
  12. Han CS, et al. Vascularized bone transfer. J Bone Joint Surg Am. 1992;74:1441–1449
  13. May JW, et al. Clinical classification of post-traumatic tibial osteomyelitis. J Bone Joint Surg Am. 1989;71:1422–1428
  14. Masquelet AC. Muscle reconstruction in reconstructive surgery: soft tissue repair and long bone reconstruction. Langenbecks Arch Surg. 2003;388:344–346
  15. Lin CH, et al. Outcome comparison in traumatic lower-extremity reconstruction by using various composite vascularized bone transplantation. Plast Reconstr Surg. 1999;104:984–992
  16. Wei FC, et al. Free fibula osteoseptocutaneous graft for reconstruction of segmental femoral shaft defects. J Trauma. 1997;43:784–792
  17. Yajima H, et al. Vascularised fibular grafts for reconstruction of the femur. J Bone Joint Surg Br. 1993;75:123–128
  18. Hou SM, Liu TK. Reconstruction of skeletal defects in the femur with ‘two-strut’ free vascularized fibular grafts. J Trauma. 1992;33:840–845
  19. Jupiter JB, Bour CJ, May JW. The reconstruction of defects in the femoral shaft with vascularized transfers of fibular bone. J Bone Joint Surg Am. 1987;69:365–374
  20. Smrke D, Arnez ZM. Treatment of extensive bone and soft tissue defects of the lower limb by traction and free-flap transfer. Injury. 2000;31:153–162
  21. Maini L, et al. The Ilizarov method in infected nonunion of fractures. Injury. 2000;31:509–517
  22. Polyzois D, et al. Treatment of tibial and femoral bone loss by distraction osteogenesis. Experience in 28 infected and 14 clean cases. Acta Orthop Scand Suppl. 1997;275:84–88
  23. Giotakis N, Narayan B, Nayagam S. Distraction osteogenesis and nonunion of the docking site: is there an ideal treatment option?. Injury. 2007;38:S100–S107
  24. Jupiter JB. Complex non-union of the humeral diaphysis. Treatment with a medial approach, an anterior plate, and a vascularized fibular graft. J Bone Joint Surg Am. 1990;72:701–707
  25. Tu YK, et al. Treatment for scaphoid fracture and nonunion—the application of 3.0 mm cannulated screws and pedicle vascularised bone grafts. Injury. 2008;39:96–106
  26. Moran CG, Wood MB. Vascularized bone autografts. Orthop Rev. 1993;22:187–197
  27. Malizos KN, et al. Free vascularized fibula in traumatic long bone defects and in limb salvaging following tumor resection: comparative study. Microsurgery. 1993;14:368–374
  28. Banic A, Hertel R. Double vascularized fibulas for reconstruction of large tibial defects. J Reconstr Microsurg. 1993;9:421–428
  29. Brunelli G, et al. Free microvascular fibular versus conventional bone grafts. Int Surg. 1991;76:33–42
  30. Peat BG, Liggins DF. Microvascular soft tissue reconstruction for acute tibial fractures—late complications and the role of bone grafting. Ann Plast Surg. 1990;24:517–520
  31. Yaremchuk MJ, et al. Acute and definitive management of traumatic osteocutaneous defects of the lower extremity. Plast Reconstr Surg. 1987;80:1–14
  32. Wei FC, et al. Fibular osteoseptocutaneous flap: anatomic study and clinical application. Plast Reconstr Surg. 1986;78:191–200
  33. Ceruso M, et al. Vascularised fibula graft inlaid in a massive bone allograft: considerations on the bio-mechanical behaviour of the combined graft in segmental bone reconstructions after sarcoma resection. Injury. 2008;39:S68–S74
  34. de Boer HH, Wood MB. Bone changes in the vascularised fibular graft. J Bone Joint Surg Br. 1989;71:374–378
  35. Yajima H, Tamai S. Twin-barrelled vascularized fibular grafting to the pelvis and lower extremity. Clin Orthop Relat Res. 1994;178–184
  36. O'Brien BM, et al. Folded free vascularized fibula transfer. Plast Reconstr Surg. 1988;82:311–318
  37. Jones NF, et al. The “double barrel” free vascularized fibular bone graft. Plast Reconstr Surg. 1988;81:378–385
  38. Lin CH, et al. Free composite serratus anterior and rib flaps for tibial composite bone and soft-tissue defect. Plast Reconstr Surg. 1997;99:1656–1665
  39. Hierner R, Wood MB. Comparison of vascularised iliac crest and vascularised fibula transfer for reconstruction of segmental and partial bone defects in long bones of the lower extremity. Microsurgery. 1995;16:818–826
  40. Nusbickel FR, et al. Vascularized autografts for reconstruction of skeletal defects following lower extremity trauma. A review. Clin Orthop Relat Res. 1989;65–70
  41. Thomas WO, et al. Versatility of the microvascular serratus anterior muscle vascularized rib flap (SARIB) for multifaceted requirement reconstructions. Ann Plast Surg. 1998;40:23–27
  42. Buncke HJ, et al. Free osteocutaneous flap from a rib to the tibia. Plast Reconstr Surg. 1977;59:799–804
  43. Minami A, et al. Vascularised fibular grafts. An experience of 102 patients. J Bone Joint Surg Br. 2000;82:1022–1025
  44. Zaretski A, et al. Free fibula long bone reconstruction in orthopedic oncology: a surgical algorithm for reconstructive options. Plast Reconstr Surg. 2004;113:1989–2000
  45. Dhar SA, et al. Management of lower limb fractures in polytrauma patients with delayed referral in a mass disaster. The role of the Ilizarov method in conversion osteosynthesis. Injury. 2008;39:947–951
  46. Bacon S, et al. A retrospective analysis of comminuted intra-articular fractures of the tibial plafond: open reduction and internal fixation versus external Ilizarov fixation. Injury. 2008;39:196–202
  47. Motsitsi NS. Management of infected nonunion of long bones: the last decade (1996–2006). Injury. 2008;39:155–160
  48. Lammens J, Van Laer M, Motmans R. Ilizarov treatment for femoral mal-union or non-union associated with fatigue fracture of an intramedullary nail. Injury. 2008;39:256–259
  49. Ozturkmen Y, et al. Acute treatment of segmental tibial fractures with the Ilizarov method. Injury. 2009;40:321–326
  50. Zamora-Munoz PM, Orellana-Reta C. Treatment of the tibial bone defects by traumatic sequels with the Ilizarov method in children. Acta Ortop Mex. 2007;21:318–322
  51. Morasiewicz L, et al. The results of treatment of bone defects and non-union within the femoral shaft with shortening of femur using Ilizarov method. Ortop Traumatol Rehabil. 2007;9:366–376
  52. Tomic S, et al. The treatment of infected diaphyseal femoral defects by lengthening one of the bone fragments by Ilizarov. Acta Chir Iugosl. 2006;53:27–31
  53. Robert Rozbruch S, et al. Simultaneous treatment of tibial bone and soft-tissue defects with the Ilizarov method. J Orthop Trauma. 2006;20:197–205
  54. El-Mowafi H, Elalfi B, Wasfi K. Functional outcome following treatment of segmental skeletal defects of the forearm bones by Ilizarov application. Acta Orthop Belg. 2005;71:157–162
  55. Rahal SC, et al. Large segmental radius and ulna defect treated by bone transportation with the Ilizarov technique. Aust Vet J. 2003;81:677–680
  56. Rose RE. The Ilizarov technique in the treatment of tibial bone defects. Case reports and review of the literature. West Indian Med J. 2002;51:263–267
  57. Golyakhovsky V, Frankel VH. Ilizarov bone transport in large bone loss and in severe osteomyelitis. Bull Hosp Jt Dis Orthop Inst. 1991;51:63–73
  58. Aronson J, Johnson E, Harp JH. Local bone transportation for treatment of intercalary defects by the Ilizarov technique. Biomechanical and clinical considerations. Clin Orthop Relat Res. 1989;71–79
  59. Aronson J, et al. Mechanical induction of Osteogenesis. Preliminary studies. Ann Clin Lab Sci. 1988;18:195–203
  60. Aronson J, et al. Mechanical induction of osteogenesis: the importance of pin rigidity. J Pediatr Orthop. 1988;8:396–401
  61. Magyar G, Toksvig-Larsen S, Moroni A. Hydroxyapatite coating of threaded pins enhances fixation. J Bone Joint Surg Br. 1997;79:487–489
  62. Zachee B, Roosen P, Mc Aechern AG. The dynamic axial fixator in fractures of the tibia and femur. A retrospective study in 98 patients. Acta Orthop Belg. 1991;57:266–271
  63. Dumont CE, Exner UG. Reconstruction of large diaphyseal defects of the femur and the tibia with autologous bone. Eur J Trauma Emerg Surg. 2009;35:17–25
  64. Fischgrund J, Paley D, Suter C. Variables affecting time to bone healing during limb lengthening. Clin Orthop Relat Res. 1994;31–37
  65. Green SA. Skeletal defects. A comparison of bone grafting and bone transport for segmental skeletal defects. Clin Orthop Relat Res. 1994;111–117
  66. Brunner UH, et al. Force required for bone segment transport in the treatment of large bone defects using medullary nail fixation. Clin Orthop Relat Res. 1994;147–155
  67. Lerner A, et al. Using the Ilizarov external fixation device for skin expansion. Ann Plast Surg. 2000;45:535–537
  68. Gopal S, et al. Fix and flap: the radical orthopaedic and plastic treatment of severe open fractures of the tibia. J Bone Joint Surg Br. 2000;82:959–966
  69. Lowenberg DW, et al. Combined muscle flap and Ilizarov reconstruction for bone and soft tissue defects. Clin Orthop Relat Res. 1996;37–51
  70. Sen C, et al. Bifocal compression–distraction in the acute treatment of grade III open tibia fractures with bone and soft-tissue loss: a report of 24 cases. J Orthop Trauma. 2004;18:150–157
  71. Lerner A, et al. Acute shortening: modular treatment modality for severe combined bone and soft tissue loss of the extremities. J Trauma. 2004;57:603–608
  72. Biau DJ, et al. Case report: reconstruction of a 16-cm diaphyseal defect after Ewing's resection in a child. Clin Orthop Relat Res. 2009;467:572–577
  73. Pelissier P, et al. Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res. 2004;22:73–79
  74. Attias N, et al. Surgical management of a long segmental defect of the humerus using a cylindrical titanium mesh cage and plates: a case report. J Orthop Trauma. 2005;19:211–216
  75. Cobos JA, Lindsey RW, Gugala Z. The cylindrical titanium mesh cage for treatment of a long bone segmental defect: description of a new technique and report of two cases. J Orthop Trauma. 2000;14:54–59
  76. Pelissier P, et al. Behaviour of cancellous bone graft placed in induced membranes. Br J Plast Surg. 2002;55:596–598
  77. Masquelet AC, et al. Reconstruction of the long bones by the induced membrane and spongy autograft. Ann Chir Plast Esthet. 2000;45:346–353
  78. Webb LX. Bone defect nonunion of the lower extremity. Tech Orthop. 2001;16:387–397
  79. Hinsche AF, et al. Spontaneous healing of large femoral cortical bone defects: does genetic predisposition play a role?. Acta Orthop Belg. 2003;69:441–446
  80. Keating JF, et al. Bone loss in open femoral fractures [abstract]. In: Proceedings of the Annual Meeting of the Orthopaedic Trauma Association 2000, 2000.
  81. Min WK, et al. Biomechanical advantage of lengthening of the femur with an external fixator over an intramedullary nail. J Pediatr Orthop B. 2007;16:39–43
  82. Paley D, et al. Femoral lengthening over an intramedullary nail. A matched-case comparison with Ilizarov femoral lengthening. J Bone Joint Surg Am. 1997;79:1464–1480
  83. Song HR, et al. Femoral lengthening over an intramedullary nail using the external fixator: risk of infection and knee problems in 22 patients with a follow-up of 2 years or more. Acta Orthop. 2005;76:245–252
  84. Gordon JE, et al. Femoral lengthening over a humeral intramedullary nail in preadolescent children. J Bone Joint Surg Am. 2002;84-A:930–937
  85. Simpson AH, Cole AS, Kenwright J. Leg lengthening over an intramedullary nail. J Bone Joint Surg Br. 1999;81:1041–1045
  86. Guichet JM, et al. Gradual femoral lengthening with the Albizzia intramedullary nail. J Bone Joint Surg Am. 2003;85-A:838–848
  87. Garcia-Cimbrelo E, et al. The intramedullary elongation nail for femoral lengthening. J Bone Joint Surg Br. 2002;84:971–977
  88. Cole JD, et al. The intramedullary skeletal kinetic distractor (ISKD): first clinical results of a new intramedullary nail for lengthening of the femur and tibia. Injury. 2001;32:SD129–SD139
  89. Hinsche AF, et al. Spontaneous healing of a 14 cm diaphyseal cortical defect of the tibia. Injury. 2003;34:385–388
  90. Taylor GI, Miller GD, Ham FJ. The free vascularized bone graft. A clinical extension of microvascular techniques. Plast Reconstr Surg. 1975;55:533–544
  91. Sowa DT, Weiland AJ. Clinical applications of vascularized bone autografts. Orthop Clin North Am. 1987;18:257–273
  92. Minami A, et al. Free vascularized fibular grafts in the treatment of congenital pseudarthrosis of the tibia. Microsurgery. 1987;8:111–116
  93. Chen ZW, et al. Treatment of tibial defect with vascularized osteocutaneous pedicled transfer of fibula. J Reconstr Microsurg. 1986;2:199–203, 205
  94. Shaffer JW, et al. Fate of vascularized and nonvascularized autografts. Clin Orthop Relat Res. 1985;32–43
  95. Osterman AL, Bora FW. Free vascularized bone grafting for large-gap nonunion of long bones. Orthop Clin North Am. 1984;15:131–142
  96. Yoshimura M, et al. Free vascularized fibular transplant. A new method for monitoring circulation of the grafted fibula. J Bone Joint Surg Am. 1983;65:1295–1301
  97. Weiland AJ, Moore JR, Daniel RK. Vascularized bone autografts. Experience with 41 cases. Clin Orthop Relat Res. 1983;87–95
  98. Taylor GI. The current status of free vascularized bone grafts. Clin Plast Surg. 1983;10:185–209
  99. Weiland AJ. Current concepts review: vascularized free bone transplants. J Bone Joint Surg Am. 1981;63:166–169
  100. Chacha PB, Ahmed M, Daruwalla JS. Vascular pedicle graft of the ipsilateral fibula for non-union of the tibia with a large defect. An experimental and clinical study. J Bone Joint Surg Br. 1981;63-B:244–253
  101. Goldberg I, Maor P, Yosipovitch Z. Congenital pseudarthrosis of the tibia treated by a pedicled vascularized graft of the ipsilateral fibula. A case report. J Bone Joint Surg Am. 1988;70:1396–1398
  102. Bowen V. Experimental free vascularized epiphyseal transplants. Orthopedics. 1986;9:893–898
  103. Chen CW, Yu ZJ, Wang Y. A new method of treatment of congenital tibial pseudoarthrosis using free vascularised fibular graft: a preliminary report. Ann Acad Med Singap. 1979;8:465–473
  104. Draeger J. Aspects of microsurgical technology. Improvement in microscopes, cutting technique and implant technology. Dev Ophthalmol. 1989;18:7–15
  105. Schuind F, Burny F, Lejeune FJ. Microsurgical free fibular bone transfer: a technique for reconstruction of large skeletal defects following resection of high-grade malignant tumors. World J Surg. 1988;12:310–317
  106. Derman GH, Schenck RR. Microsurgical technique—fundamentals of the microsurgical laboratory. Orthop Clin North Am. 1977;8:229–248
  107. Fundamentals of microsurgical technique. Adv Ophthalmol. 1972;27:49–89
  108. Jacobson JH, Suarez EL. Microvascular surgery. Dis Chest. 1962;41:220–224
  109. Gore DR, et al. Function following partial fibulectomy. Clin Orthop Relat Res. 1987;206–210
  110. Goldberg VM, Stevenson S. Natural history of autografts and allografts. Clin Orthop Relat Res. 1987;7–16
  111. Goldberg VM, et al. Biology of vascularized bone grafts. Orthop Clin North Am. 1987;18:197–205
  112. Zinberg EM, Wood MB, Brown ML. Vascularized bone transfer: evaluation of viability by postoperative bone scan. J Reconstr Microsurg. 1985;2:13–19
  113. Toh S, et al. Combining free vascularized fibula graft and the Ilizarov external fixator: recent approaches to congenital pseudarthrosis of the tibia. J Reconstr Microsurg. 2001;17:497–508discussion 509
  114. Hsu RW, et al. Free vascularised fibular grafting for reconstruction after tumour resection. J Bone Joint Surg Br. 1997;79:36–42
  115. Alman BA, De Bari A, Krajbich JI. Massive allografts in the treatment of osteosarcoma and Ewing sarcoma in children and adolescents. J Bone Joint Surg Am. 1995;77:54–64
  116. Pollock R, et al. Free vascularized fibula grafts in limb-salvage surgery. J Reconstr Microsurg. 2005;21:79–84
  117. Fuchs B, et al. Arthrodesis of the shoulder after tumor resection. Clin Orthop Relat Res. 2005;202–207
  118. Bernd L, et al. Experiences with vascular pedicled fibula in reconstruction of osseous defects in primary malignant bone tumors. Orthopade. 2003;32:983–993
  119. Ceruso M, et al. Skeletal reconstruction with a free vascularized fibula graft associated to bone allograft after resection of malignant bone tumor of limbs. Handchir Mikrochir Plast Chir. 2001;33:277–282
  120. Vail TP, Urbaniak JR. Donor-site morbidity with use of vascularized autogenous fibular grafts. J Bone Joint Surg Am. 1996;78:204–211
  121. Muller ME. Treatment of nonunions by compression. Clin Orthop Relat Res. 1965;43:83–92
  122. Ilizarov GA, et al. Reparative regeneration of the bone tissue after correction of defects of the long tubular bones by lengthening of one of the fragments (experimental study). Eksp Khir Anesteziol. 1975;37–42
  123. Ilizarov GA. Basic principles of transosseous compression and distraction osteosynthesis (translated from Russian). Ortop Travmatol Protez. 1975;10:
  124. D'Hooghe P, et al. Management of a large post-traumatic skin and bone defect using an Ilizarov frame. Acta Orthop Belg. 2006;72:214–218
  125. Pavolini B, et al. The Ilizarov fixator in trauma: a 10-year experience. J Orthop Sci. 2000;5:108–113
  126. Paley D, Maar DC. Ilizarov bone transport treatment for tibial defects. J Orthop Trauma. 2000;14:76–85
  127. Owen MA. Use of the Ilizarov method to manage a septic tibial fracture nonunion with a large cortical defect. J Small Anim Pract. 2000;41:124–127
  128. Stanitski DF, et al. Results of femoral lengthening using the Ilizarov technique. J Pediatr Orthop. 1995;15:224–231
  129. Green SA, et al. Management of segmental defects by the Ilizarov intercalary bone transport method. Clin Orthop Relat Res. 1992;136–142
  130. Cattaneo R, Catagni M, Johnson EE. The treatment of infected nonunions and segmental defects of the tibia by the methods of Ilizarov. Clin Orthop Relat Res. 1992;143–152
  131. Villa A, et al. Lengthening of the forearm by the Ilizarov technique. Clin Orthop Relat Res. 1990;125–137
  132. Cattaneo R, et al. Lengthening of the humerus using the Ilizarov technique. Description of the method and report of 43 cases. Clin Orthop Relat Res. 1990;117–124
  133. Song HR, et al. Comparison of internal bone transport and vascularized fibular grafting for femoral bone defects. J Orthop Trauma. 2003;17:203–211
  134. Simpson AH, Shalaby H, Keenan G. Femoral lengthening with the Intramedullary Skeletal Kinetic Distractor. J Bone Joint Surg Br. 2009;91:955–961
  135. Baumgart R, Betz A, Schweiberer L. A fully implantable motorized intramedullary nail for limb lengthening and bone transport. Clin Orthop Relat Res. 1997;135–143
  136. Hankemeier S, et al. Limb lengthening with the Intramedullary Skeletal Kinetic Distractor (ISKD). Oper Orthop Traumatol. 2005;17:79–101
  137. Hankemeier S, et al. Improved comfort in lower limb lengthening with the intramedullary skeletal kinetic distractor. Principles and preliminary clinical experiences. Arch Orthop Trauma Surg. 2004;124:129–133
  138. Dahl MT, Gulli B, Berg T. Complications of limb lengthening. A learning curve. Clin Orthop Relat Res. 1994;10–18
  139. Gugala Z, Gogolewski S. Healing of critical-size segmental bone defects in the sheep tibiae using bioresorbable polylactide membranes. Injury. 2002;33:B71–B76
  140. Meinig RP, et al. Bone regeneration with resorbable polymeric membranes: treatment of diaphyseal bone defects in the rabbit radius with poly(L-lactide) membrane. A pilot study. J Orthop Trauma. 1996;10:178–190
  141. Urist MR, et al. Human bone morphogenetic protein (hBMP). Proc Soc Exp Biol Med. 1983;173:194–199
  142. Urist MR, DeLange RJ, Finerman GA. Bone cell differentiation and growth factors. Science. 1983;220:680–686
  143. Salkeld SL, et al. The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone. J Bone Joint Surg Am. 2001;83-A:803–816
  144. Friedlaender GE, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001;83-A:S151–S158
  145. Cook SD, et al. The Otto Aufranc Award. Strut allograft healing to the femur with recombinant human osteogenic protein-1. Clin Orthop Relat Res. 2000;47–57
  146. Giannoudis PV, et al. Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions. Injury. 2007;38:S43–S48
  147. Schmidmaier G, et al. Use of bone morphogenetic proteins for treatment of non-unions and future perspectives. Injury. 2007;38:S35–S41
  148. Kanakaris NK, et al. Biological enhancement of tibial diaphyseal aseptic non-unions: the efficacy of autologous bone grafting, BMPs and reaming by-products. Injury. 2007;38:S65–S75
  149. Vaibhav B, et al. Bone morphogenic protein and its application in trauma cases: a current concept update. Injury. 2007;38:1227–1235
  150. Kanakaris NK, et al. Application of BMP-7 to tibial non-unions: a 3-year multicenter experience. Injury. 2008;39:S83–S90
  151. Barboza EP, et al. Effect of recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge with space-providing biomaterials on the augmentation of chronic alveolar ridge defects. J Periodontol. 2004;75:702–708
  152. Kokubo S, et al. Bone regeneration by recombinant human bone morphogenetic protein-2 and a novel biodegradable carrier in a rabbit ulnar defect model. Biomaterials. 2003;24:1643–1651
  153. Chen X, Kidder LS, Lew WD. Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur. J Orthop Res. 2002;20:142–150
  154. Yudell RM, Block MS. Bone gap healing in the dog using recombinant human bone morphogenetic protein-2. J Oral Maxillofac Surg. 2000;58:761–766
  155. Tuominen T, et al. Native bovine bone morphogenetic protein improves the potential of biocoral to heal segmental canine ulnar defects. Int Orthop. 2000;24:289–294
  156. Sciadini MF, Johnson KD. Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model. J Orthop Res. 2000;18:289–302
  157. Hollinger JO, et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res. 1998;43:356–364
  158. Viljanen VV, et al. Xenogeneic moose (Alces alces) bone morphogenetic protein (mBMP)-induced repair of critical-size skull defects in sheep. Int J Oral Maxillofac Surg. 1996;25:217–222
  159. Gao TJ, et al. Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, and type IV collagen. J Biomed Mater Res. 1996;32:505–512
  160. Moore JC, et al. Craniofacial osseous restoration with osteoinductive proteins in a collagenous delivery system. Int J Oral Maxillofac Surg. 1990;19:172–176
  161. Donati D, et al. OP-1 application in bone allograft integration: preliminary results in sheep experimental surgery. Injury. 2008;39:S65–S72
  162. Giannoudis PV, et al. The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions. Clin Orthop Relat Res. 2009;
  163. Dimitriou R, et al. Application of recombinant BMP-7 on persistent upper and lower limb non-unions. Injury. 2005;36:S51–S59
  164. Burkhart KJ, Rommens PM. Intramedullary application of bone morphogenetic protein in the management of a major bone defect after an Ilizarov procedure. J Bone Joint Surg Br. 2008;90:806–809
  165. Baltzer AW, Lieberman JR. Regional gene therapy to enhance bone repair. Gene Ther. 2004;11:344–350
  166. Dahabreh Z, Dimitriou R, Giannoudis PV. Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7. Injury. 2007;38:371–377
  167. Hsu WK, et al. Lentiviral-mediated BMP-2 gene transfer enhances healing of segmental femoral defects in rats. Bone. 2007;40:931–938
  168. Drosse I, et al. Tissue engineering for bone defect healing: an update on a multi-component approach. Injury. 2008;39:S9–20
  169. Giannoudis PV, et al. The diamond concept—open questions. Injury. 2008;39:S5–S8
  170. Soucacos PN, Johnson EO, Babis G. An update on recent advances in bone regeneration. Injury. 2008;39:S1–S4
  171. Stoop R. Smart biomaterials for tissue engineering of cartilage. Injury. 2008;39:S77–S87
  172. Haasper C, et al. Tissue engineering of osteochondral constructs in vitro using bioreactors. Injury. 2008;39:S66–S76
  173. Fuchs B, et al. Intercalary segmental reconstruction after bone tumor resection. Eur J Surg Oncol. 2008;34:1271–1276
  174. Mistry AS, Mikos AG. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol. 2005;94:1–22
  175. Hu Y, et al. Development of a porous poly(L-lactic acid)/hydroxyapatite/collagen scaffold as a BMP delivery system and its use in healing canine segmental bone defect. J Biomed Mater Res A. 2003;67:591–598
  176. Hasharoni A, et al. Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2. J Neurosurg Spine. 2005;3:47–52
  177. Shen HC, et al. Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4. J Gene Med. 2004;6:984–991
  178. Peng H, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest. 2002;110:751–759
  179. Lee JY, et al. Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum Gene Ther. 2002;13:1201–1211
  180. Gysin R, et al. Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats. Gene Ther. 2002;9:991–999
  181. Turgeman G, et al. Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med. 2001;3:240–251
  182. Baltzer AW, et al. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther. 2000;7:734–739
  183. Southwood LL, et al. Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model. J Orthop Res. 2004;22:66–72
  184. Wang JC, et al. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am. 2003;85-A:905–911
  185. Riew KD, et al. Thoracoscopic intradiscal spine fusion using a minimally invasive gene-therapy technique. J Bone Joint Surg Am. 2003;85-A:866–871
  186. Park J, et al. Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther. 2003;10:1089–1098
  187. Lieberman JR, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am. 1999;81:905–917
  188. Naldini L, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996;272:263–267
  189. Dai Y, et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA. 1995;92:1401–1405
  190. Wilson JM. Adenoviruses as gene-delivery vehicles. N Engl J Med. 1996;334:1185–1187
  191. Crystal RG. Transfer of genes to humans: early lessons and obstacles to success. Science. 1995;270:404–410
  192. Davidson BL, et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet. 1993;3:219–223
  193. Manilla P, et al. Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector. Hum Gene Ther. 2005;16:17–25

PII: S1877-1327(09)00170-5

doi: 10.1016/j.mporth.2009.10.003

Orthopaedics and Trauma
Volume 24, Issue 2 , Pages 149-163 , April 2010

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